Metasurface for broadband coherent Raman signal enhancement beyond the single-molecule detection threshold

Wafer-scale metasurface for total power absorption, local field enhancement and single molecule Raman spectroscopy

The ability to detect molecules at low concentrations is highly desired for applications that range from basic science to healthcare. Considerable interest also exists for ultrathin materials with high optical absorption, e.g. for microbolometers and thermal emitters. Metal nanostructures present opportunities to achieve both purposes. Metal nanoparticles can generate gigantic field enhancement...

Giant Raman enhancement on nanoporous gold film by conjugating with nanoparticles for single-molecule detection

Broadband Coherent Anti-Stokes Raman Scattering

Broadband coherent anti-Stokes Raman scattering (BCARS) microspectroscopy is a unique label-free imaging modality that provides detailed chemical information at each pixel. In minutes, this technique captures a “hyperspectral” cube that co-registers microscopic spatial features with chemical signatures, sensitive to molecular content and structure. This technique can delve into the molecular in...

Removing Orientation-Induced Localization Biases in Single-Molecule Microscopy Using a Broadband Metasurface Mask

Nanoscale localization of single molecules is a crucial function in several advanced microscopy techniques, including single-molecule tracking and wide-field super-resolution imaging 1. To date, a central consideration of such techniques is how to optimize the precision of molecular localization. However, as these methods continue to push toward the nanometre size scale, an increasingly importa...

Raman enhancement on a broadband meta-surface.

Plasmonic metamaterials allow confinement of light to deep subwavelength dimensions, while allowing for the tailoring of dispersion and electromagnetic mode density to enhance specific photonic properties. Optical resonances of plasmonic molecules have been extensively investigated; however, benefits of strong coupling of dimers have been overlooked. Here, we construct a plasmonic meta-surface ...